Profitability assessment is one of the main indicators in assessing the financial health of a company or the industrial sector as a whole. This study aims to analyze the financial performance across industrial sectors in Indonesia during the period 2020–2024 using the DuPont Analysis approach. The DuPont model allows the decomposition of Return on Equity (ROE) into three main components, namely Net Profit Margin, Total Asset Turnover, and Equity Multiplier, thus providing a more comprehensive picture of the factors that influence profitability. Data were obtained from the annual financial reports of companies listed on the Indonesia Stock Exchange (IDX), representing major sectors such as manufacturing, infrastructure, finance, and consumption. The results of the analysis show significant differences in ROE levels between sectors, which are influenced by variations in operational efficiency, asset utilization, and capital structure. The financial sector has the highest ROE, mainly due to high leverage, while the manufacturing sector stands out in terms of operational efficiency. On the other hand, the infrastructure sector shows low ROE due to the high burden of long-term investments. These findings indicate that the DuPont model is effective in identifying sources of strength and weakness in the profitability of each sector, and can be used as an analytical tool for investors, financial analysts, and policy makers in portfolio management and evaluation of industrial sector policies.