This study examines the potential of developing electronic student worksheets (E-LKPD) based on Problem-Based Learning (PBL) combined with virtual laboratory simulations to enhance students' scientific literacy. The study employed a systematic literature review method involving 25 selected articles, comprising 15 from reputable national journals and 10 from credible international journals. The findings indicate that PBL-based E-LKPDs incorporating virtual laboratory simulations play a significant role in improving students' scientific literacy. Research shows that integrating virtual laboratory simulations into E-LKPDs supports investigative activities, problem-solving, and the exploration of scientific concepts. Based on the literature analysis, it is concluded that developing E-LKPDs that integrate virtual laboratory simulations with the Problem-Based Learning approach is a promising strategy for enhancing students' scientific literacy. The practical implications of this study suggest combining E-LKPDs, PBL, and virtual laboratory simulations in science education to foster a learning process that is more interactive, contextual, and student-oriented.