Backgound: Chronic Kidney Disease (CKD) is a progressive condition characterized by irreversible decline in kidney function, requiring long-term treatment such as hemodialysis. This condition may lead to various psychological problems, particularly anxiety. Unmanaged anxiety can negatively affect patients' quality of life and treatment outcomes. One non-pharmacological intervention that can be used to reduce anxiety is the deep breathing relaxation technique. Objective: To describe the implementation of the deep breathing relaxation technique as an effort to reduce anxiety levels in patients with Chronic Kidney Disease through a nursing care approach. Methods: This study employed a case study design involving one subject, a patient with Chronic Kidney Disease undergoing hemodialysis at RS Balung. Data were collected through interviews, observation, documentation, and anxiety assessment using the Hamilton Anxiety Rating Scale (HARS). The deep breathing relaxation intervention was administered for three consecutive days, with a duration of 10–15 minutes per session. Data were analyzed descriptively and presented in narrative and tabular forms. Results: Prior to the intervention, the patient experienced moderate anxiety with a HARS score of 22. The patient reported worries about his health condition, fear of disease progression, and sleep disturbances. After receiving the deep breathing relaxation intervention for three consecutive days, the HARS score decreased to 14, indicating mild anxiety. In addition, the patient appeared more relaxed, calmer, and better able to control feelings of worry. Conclusion: The implementation of the deep breathing relaxation technique helped reduce anxiety levels in a patient with Chronic Kidney Disease. This intervention is a simple, safe, and easy-to-perform non-pharmacological nursing intervention that can be applied as part of nursing care to address the psychological needs of patients